Antônio C. Roque

This paper presents a computational model of astrocyte Ca2+ and IP3 dynamics to explain how diverse Ca2+ signaling patterns emerge from parameter changes and transmembrane currents.

This study uses computational models to show dopamine reduces glutamatergic input frequency needed to evoke calcium signals in astrocytes, depending on cell morphology.

This study investigates how disruptions in the excitation-inhibition balance affect decision-making in a cortical circuit model, finding that both elevated and reduced E/I ratios impair decision-making in distinct ways.

This paper develops a theory showing that E/I synaptic balance, asynchronous irregular firing, and power-law neuronal avalanches can coexist in a network with specific adaptation mechanisms.

The paper develops a computational model to show that betaCaMKII regulates bidirectional synaptic plasticity in cerebellar Purkinje cells through actin binding and AMPA receptor phosphorylation.

The paper develops a computational model to show that βCaMKII regulates bidirectional plasticity at PF-PC synapses through actin binding and phosphorylation-dephosphorylation balance of AMPA receptors.

The paper compares the Goalkeeper Game (GG) and MoCA tests for predicting gait performance in Parkinson's disease patients, finding GG has slightly better predictive power.

This paper replicates the Potjans-Diesmann cortical microcircuit model in Brian 2, achieving similar activity dynamics as the original NEST implementation.