Author

Duojiao Chen

Indiana University IndianapolisORCID 0000-0003-1260-7435Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Aditi Sanjay KhatpeiD· 2 shared Anna Maria StornioloiD· 2 shared Cihat ErdoğaniD· 2 shared George Earl SanduskyiD· 2 shared Harikrishna NakshatriiD· 2 shared Hongyu GaoiD· 2 shared Patrick C. McGuireiD· 2 shared Poornima Bhat‐NakshatriiD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Aditi Sanjay KhatpeORCID

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2 papers

Recent·Most cited

Cancer BiologyNature MedicinePeer-reviewedAug 9, 2024

Single nuclei chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry

Poornima Bhat‐Nakshatri, Hongyu Gao, Aditi Sanjay Khatpe…·Harikrishna Nakshatri

The paper develops a chromatin accessibility and gene expression atlas of human breast tissues from 92 donors of diverse genetic ancestry, identifying 10 cell types and ancestry-dependent gene expression patterns.

30 citations

humanscRNA-seq

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Cancer BiologyCancer Research CommunicationsPeer-reviewedDec 7, 2023

BRCA1 and BRCA2 germline mutations driven signaling pathway alterations are sufficient to initiate breast tumorigenesis by the PIK3CAH1047R oncogene.

Poornima Bhat‐Nakshatri, Aditi Sanjay Khatpe, Duojiao Chen…·Harikrishna Nakshatri

This paper compares single-cell transcriptomes of BRCA1/2 mutation carriers and non-carriers to show how these mutations alter signaling pathways and drive breast cancer development through PIK3CA mutations.

14 citations

humanscRNA-seq

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