Hongyu Gao

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

The paper shows that lipid metabolism, specifically through OA, shifts metabolic pathways in breast cells, increasing SAM and 2-HG, which contribute to oncogenic properties and epigenetic changes.

The paper uses multiomic profiling of the caudate nucleus to identify gene expression and chromatin changes in AUD, linking them to risk genes through QTL analysis.

This study uses spatial transcriptomics to analyze a spinal ependymoma tumor, revealing cellular heterogeneity and potential developmental hierarchy within the ependymal cell lineage.

The paper identifies functional 3'-UTR variants linked to alcohol use disorder and related traits using MPRA and GWAS integration.

The paper identifies AREG as a critical driver of bleomycin-induced skin fibrosis and shows that targeting the AREG-EGFR-MEK pathway can prevent fibrosis.

This study uses single-cell RNA sequencing to define the temporal cellular and molecular changes in the kidney during sepsis, identifying key gene expression shifts and communication failures that mark critical points in the sepsis timeline.

Stepwise modulation of TGFβ, BMP, and FGF signaling in human pluripotent stem cell aggregates generates innervated, pigmented hair-bearing skin organoids that form planar human skin when grafted onto nude mice.

This paper shows that Rtr1 prevents premature transcription termination by restricting the NNS-dependent termination pathway and facilitating low-level elongation of noncoding transcripts.

The paper identifies functional variants in human brains with alcohol use disorders by combining allele-specific expression analysis with high-throughput reporter assays.