Diverse epigenomic mechanisms underpin transcriptional dysregulation in Polycomb-altered acute myeloid leukemia
Cosmin Tudose, Luke Jones, Theodora-Ioana Grosu, Marie-Claire Fitzgerald, Noura Maziak, Rebecca E. Ling, Anindita Roy, Juan M. Vaquerizas, Colm J. Ryan, Jonathan Bond
This study investigates how PRC2 depletion in AML affects epigenomic and transcriptional changes, revealing altered chromatin accessibility, H3K27me3 levels, and gene expression patterns that impact cell phenotype and treatment response.
bioRxiv · Aug 28, 2025 · PreprintCancer Biology