William A. Faubion

This study shows that extended normothermic machine perfusion preserves human intestinal tissue viability and function for up to 72 hours, enabling mechanistic studies of inflammation and personalized therapy testing.

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

This study shows that intestinal stem cells from IBD patients retain epigenetic memory of inflammation, leading to heightened responses to future injury but also increased risk of relapse.

The paper analyzes over 800,000 human genomes to assess penetrance of clinically relevant variants, finding that 95% of pLoF variants in severe diseases have explanations for lack of disease manifestation.

This study shows that metabolic reprogramming of Th1 cells via GSK3β inhibition reduces inflammation in IBD by suppressing glycolysis and cytokine production.

The paper identifies novel target genes associated with IBD by analyzing eQTL in diseased colon tissue and comparing them to non-IBD eQTL.

The paper identifies ten new genes with coding variants linked to Crohn's disease risk using sequencing data from over 30,000 patients and 80,000 controls.