Leonid W. Lecca

The paper compares the transcriptional profiles of CD1b-specific T cells with conventional and innate-like T cells, finding CD1b-specific cells are more similar to conventional T cells.

The paper identifies variants in Mycobacterium tuberculosis associated with decreased virulence gene expression and increased transmissibility, particularly in drug-resistant strains.

This study finds that higher Native Peruvian ancestry is associated with increased tuberculosis progression risk, independent of socio-demographic and environmental factors.

The paper identifies a sex-specific evolutionary interaction between ADCY9 and CETP variants associated with dalcetrapib response and cardiovascular traits.

The paper identifies state-dependent eQTLs in memory T cells by analyzing single-cell RNA and protein data from Peruvians, showing that gene regulation varies with cell states and disease-associated variants are enriched in these contexts.

The paper investigates the association between dysglycemia and Mycobacterium tuberculosis lineages in TB patients, finding specific lineages linked to diabetes and pre-diabetes comorbidities.

The paper identifies a genetic variant on 3q23 associated with early progression from Mycobacterium tuberculosis exposure to active tuberculosis in Peruvians, showing higher heritability than general TB susceptibility.

A common missense variant in FBN1 reduces height by 2.2 cm in Peruvians, showing strong positive selection and higher frequency in coastal Native American populations.