Samira Asgari

A Scalable Framework to Integrate Social Determinants of Health into Disease Risk Models using Biobank Survey Data

This paper introduces a framework to integrate social determinants of health into disease risk models using biobank survey data, showing improved prediction beyond genetic factors.

Shared genetic and neuroimmune architecture links type 1 diabetes with neurocognitive traits

This paper identifies shared genetic and neuroimmune mechanisms linking type 1 diabetes with neurocognitive traits through genome-wide association and single-cell epigenomic analyses.

Past viral infections can shape inter-individual variability in anti-viral TLR responses

This study links past viral infections to variability in anti-viral TLR responses by combining serological data with functional immune profiling.

Systematic comparison of phenome-wide admixture mapping and genome-wide association in a diverse biobank

This study compares phenome-wide admixture mapping and genome-wide association in a diverse biobank, finding 77 significant AM signals, 48 missed by GWAS.

Genetic relations between leukocyte counts, type 1 diabetes, and coronary artery disease

This study identifies shared genetic determinants between type 1 diabetes, coronary artery disease, and leukocyte counts, showing genetic associations between leukocyte counts and both diseases.

High-dimensional phenotyping to define the genetic basis of cellular morphology

This study identifies genetic variants associated with cellular morphology using high-content imaging and genomic data from iPSCs.

Admixture Mapping of Peripheral Artery Disease in a Dominican Population Reveals a Novel Risk Locus on 2q35

The paper identifies a novel risk locus for PAD on 2q35 in Dominicans using admixture mapping and health systems data.

Higher Native Peruvian ancestry proportion is associated with tuberculosis progression risk

This study finds that higher Native Peruvian ancestry is associated with increased tuberculosis progression risk, independent of socio-demographic and environmental factors.

A sex-specific evolutionary interaction between ADCY9 and CETP

The paper identifies a sex-specific evolutionary interaction between ADCY9 and CETP variants associated with dalcetrapib response and cardiovascular traits.

Modeling memory T cell states at single-cell resolution identifies in vivo state-dependence of eQTLs influencing disease

The paper identifies state-dependent eQTLs in memory T cells by analyzing single-cell RNA and protein data from Peruvians, showing that gene regulation varies with cell states and disease-associated variants are enriched in these contexts.

Axes of inter-sample variability among transcriptional neighborhoods reveal disease associated cell states in single-cell data

This paper introduces CNA, a method to identify disease-associated cell states by analyzing transcriptional neighborhoods across samples, showing improved performance over cluster-based approaches in simulations and real datasets.

Progression of recent Mycobacterium tuberculosis exposure to active tuberculosis is a highly heritable complex trait driven by 3q23 in Peruvians

The paper identifies a genetic variant on 3q23 associated with early progression from Mycobacterium tuberculosis exposure to active tuberculosis in Peruvians, showing higher heritability than general TB susceptibility.

A positively selected, common, missense variant in FBN1 confers a 2.2 centimeter reduction of height in the Peruvian population

A common missense variant in FBN1 reduces height by 2.2 cm in Peruvians, showing strong positive selection and higher frequency in coastal Native American populations.

Human genomics of acute liver failure due to hepatitis B virus infection: an exome sequencing study in liver transplant recipients

This study uses exome sequencing to investigate genetic factors contributing to acute liver failure from HBV infection in liver transplant recipients but finds no causal variants.