William James Greenleaf

The paper uses single-cell chromatin accessibility to map the continuous regulatory variation in human hematopoietic differentiation and identifies epigenomic heterogeneity within cell populations.

HiChIP improves the yield and reduces input requirements of chromatin conformation analysis, revealing multi-scale genome architecture with better signal-to-background.

The paper identifies significantly mutated regions (SMRs) across cancer genomes to uncover functional molecular alterations, revealing diverse mutation patterns and their associations with gene expression and protein domains.