This study investigates the long-term effects of prenatal methadone exposure on cognitive function and hippocampal neurogenesis in offspring, finding female-specific impairments in fear responding and reduced survival of adult-born neurons.

6 citations

ratexperimental assay

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NeuroscienceAddiction BiologyPeer-reviewedJul 27, 2022

Prenatal methadone exposure leads to long-term memory impairments and disruptions of dentate granule cell function in a sex-dependent manner

Meredith E. Gamble, Rhea Marfatia, Marvin Rafael Diaz

This study examines the long-term cognitive and neural effects of prenatal methadone exposure on adult rats, revealing sex-dependent memory impairments and hippocampal dysfunction.

14 citations

ratexperimental assay

𝕏 PostBluesky

NeuroscienceNeuropharmacologyPeer-reviewedMar 2, 2021

Moderate adolescent chronic intermittent ethanol exposure sex-dependently disrupts synaptic transmission and kappa opioid receptor function in the basolateral amygdala of adult rats

Kathryn R. Przybysz, Meredith E. Gamble, Marvin Rafael Diaz

This study shows that moderate adolescent ethanol exposure causes long-term sex-dependent changes in BLA physiology and KOR function in adult rats.

11 citations

ratelectronic health records

𝕏 PostBluesky