BiochemistryJournal of Biological ChemistryPeer-reviewed
Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis
Jeung‐Hoi Ha, Yikang Xu, Harsimranjit Sekhon…·Stewart N. Loh
This study shows that kidney-like flow shear in microfluidic devices efficiently induces LECT2 aggregation, with the I40V mutation enhancing fibril formation and aggregate size.
10 citations