Author

Melanie A. Higgins

University of British ColumbiaORCID 0000-0003-1485-1378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

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Approach:experimental assay· 1

Frequent Co-Authors

Jill B. HarlandiD· 1 shared Jordi SoleriD· 1 shared Katherine S. RyaniD· 1 shared Marc Garcia‐BorràsiD· 1 shared Nicolai LehnertiD· 1 shared Taylor Parkkila· 1 shared Xinjie ShiiD· 1 shared Yi‐Ling DuiD· 1 shared

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2025-2025 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperBiochemistry

Jill B. HarlandORCID

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1 paper

Recent·Most cited

BiochemistryNature CatalysisPeer-reviewedFeb 13, 2025

Structural and mechanistic views of enzymatic, heme-dependent nitrogen-nitrogen bond formation

Melanie A. Higgins, Xinjie Shi, Jordi Soler…·Katherine S. Ryan

This study investigates the structural and mechanistic basis of N-N bond formation by the heme-dependent enzyme PipS, revealing divergent pathways and a shared nitrenoid intermediate.

21 citations

experimental assay

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