This study identifies a network involving oligodendroglial precursors and immune cells that drives early demyelination in EAE, showing that targeting CCL4 disrupts this cycle.

2 citations

mouseexperimental assay

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BioinformaticsBriefings in BioinformaticsPeer-reviewedMar 18, 2021

TIPS: Trajectory Inference of Pathway Significance through Pseudotime Comparison for Functional Assessment of single-cell RNAseq Data

Zihan Zheng, X. Qiu, Haiyang Wu…·Qingshan Ni

TIPS assesses pathway and transcription factor contributions to developmental trajectories in scRNAseq data through pseudotime comparison and provides visualization tools.

15 citations

scRNA-seqstatistical model

𝕏 PostBluesky

GenomicsbioRxivPreprintApr 15, 2020

scSTATseq: Diminishing Technical Dropout Enables Core Transcriptome Recovery and Comprehensive Single-cell Trajectory Mapping

Zihan Zheng, Xiangyu Tang, Xin Qiu…·Ying Wan

scSTATseq reduces technical dropout in scRNA-seq, enabling comprehensive transcriptome recovery and trajectory mapping, as demonstrated in osteoclast differentiation analysis.

2 citations

scRNA-seqexperimental assay

𝕏 PostBluesky

GenomicsJournal of Molecular BiologyPeer-reviewedSep 3, 2019

Streamlined low-input transcriptomics through EASY-RNAseq

Yiwen Zhou, Hao Xu, Haiyang Wu…·Ying Wan

EASY-RNAseq is a low-input RNAseq protocol that improves gene detection sensitivity and expression distribution in small cell populations.

26 citations

humanbulk RNA-seq

𝕏 PostBluesky