Author

Hans‐Gerd Fieguth

Klinikum Region HannoverORCID 0000-0003-1559-158XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Christina HesseiD· 2 shared Lena Willmer· 2 shared Patrick ZardoiD· 2 shared Adarsh M. KumariD· 1 shared Aimo KanntiD· 1 shared Anita WegertiD· 1 shared Arne Hackspacher· 1 shared Astrid Brüggerhoff· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Christina HesseORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 13, 2025

Tankyrase inhibition demonstrates anti-fibrotic effects in preclinical pulmonary fibrosis models

Shoshy Alam Brinch, Ida Johnsen, Lena Willmer…·Jo Waaler

This study shows that the TNKS inhibitor OM-153 reduces fibrosis markers and ECM expression in multiple preclinical IPF models by inhibiting WNT/β-catenin and YAP signaling.

DOI 10.1101/2025.11.13.688191

humanbulk RNA-seq

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BiochemistryJournal of Medicinal ChemistryPeer-reviewedJun 18, 2025

STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE

Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan…·Kerstin Hiesinger

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

11 citations

humanprotein structure

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