Author

Lena Willmer

Fraunhofer Institute for Toxicology and Experimental Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Christina HesseiD· 2 shared Hans‐Gerd FieguthiD· 2 shared Patrick ZardoiD· 2 shared Adarsh M. KumariD· 1 shared Aimo KanntiD· 1 shared Anita WegertiD· 1 shared Arne Hackspacher· 1 shared Astrid Brüggerhoff· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Christina HesseORCID

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2 papers

Recent·Most cited

Tankyrase inhibition demonstrates anti-fibrotic effects in preclinical pulmonary fibrosis models

Shoshy Alam Brinch, Ida Johnsen, Lena Willmer, Ole Vidhammer Bjørnstad, Teresa Lucifora, Karl Martin Forbord, María Candamo-Lourido, Maureen Tania Meling, Ingrid Lofthus Morken, Martin Frank Strand, Danny David Jonigk, Patrick Zardo, Hans‐Gerd Fieguth, Christina Hesse, Mark Alexander Skarsfeldt, , Jo Waaler

This study shows that the TNKS inhibitor OM-153 reduces fibrosis markers and ECM expression in multiple preclinical IPF models by inhibiting WNT/β-catenin and YAP signaling.

bioRxiv · Nov 13, 2025 · PreprintCell Biology

STRUCTURE-BASED DESIGN OF PROTACS FOR THE DEGRADATION OF SOLUBLE EPOXIDE HYDROLASE

Julia Schönfeld, Steffen Brunst, Ludmila Ciomirtan, Lena Willmer, Michel André Chromik, Adarsh M. Kumar, Timo Frömel, Nick Liebisch, Arne Hackspacher, Johanna H. M. Ehrler, Lukas Wintermeier, Christina Hesse, Jan Fiedler, Jan Heering, Hinrich Freitag, , Kerstin Hiesinger

This paper designs and tests sEH-PROTACs to degrade soluble epoxide hydrolase, identifying PROTAC 23 as effective in degrading sEH in human macrophages.

Journal of Medicinal Chemistry · Jun 18, 2025Peer-reviewedBiochemistry