Chunyan Tian

MEGA-ODE reconstructs dynamic omics landscapes from sparse data, predicts unmeasured states, and prioritizes perturbations toward biological endpoints.

This study identifies THOC2 as a regulator of DNA repair and growth in HCC, showing that targeting THOC2 enhances PARPi efficacy by disrupting mRNA export of DDR genes.

This paper introduces a simple one-step vial-based pretreatment method for deep single-cell proteomics and applies it to study oocyte aging, identifying age-related protein markers.

The paper introduces BiFC-seq, a yeast-based method for genome-wide interactome mapping, and demonstrates its application to Ebola virus and p53 interactomes, identifying known and novel interactions.