Edward J. Hancock

This paper introduces an extended antithetic control motif stabilized by molecular buffering to achieve robust perfect adaptation in synthetic biology circuits.

The paper uses control theory and buffer analysis to show that buffering enables independent control of ATP and adenylate energy ratios in metabolism, supported by human and mouse data.

This paper designs and builds two synthetic negative feedback circuits using engineered small RNAs, showing they can fine-tune output and reduce noise compared to traditional protein-based systems.