James Robert Krycer

The paper shows that inhibiting contractile function in cardiomyocytes reactivates the cell cycle, suggesting active contraction maintains differentiation and cell cycle arrest.

This study shows that maturing human cardiac organoids enhances disease modeling and drug discovery by mimicking in vivo development and enabling therapeutic testing for DSP cardiomyopathy.

This study uses phosphoproteomics to show that insulin resistance involves rewired signaling networks and widespread dysregulation of GSK3 activity.

The paper identifies diet-responsive genes in Drosophila by analyzing genetic variation across diets and confirms their role in nutrient storage and utilization.

The paper uses control theory and buffer analysis to show that buffering enables independent control of ATP and adenylate energy ratios in metabolism, supported by human and mouse data.

The paper introduces a method to infer temporal ordering of omics events from time series data with higher resolution than the experiment, using event maps and sparklines for visualization.