Yun-Chien Chang

This study investigates the role of PIMREG in DNA damage response in GBM cells, finding that its loss impairs double-strand break signaling and repair.

This study uses pan-cancer phosphoproteomics to identify therapeutic targets and improve precision oncology by analyzing 1,998 tumor samples and developing new scores for kinase activity and immune response.

The paper develops a method to identify and validate kinase-substrate relationships using phosphoproteomics data and applies it to estimate kinase activity in cancer biopsies.

The paper uses chemical proteomics to analyze KRAS inhibitor effects on signaling networks in cancer cells, revealing cell-specific responses and phosphorylation changes.

This study identifies UHMK1 as a splicing regulatory kinase by showing its role in phosphorylation, alternative splicing, and cellular processes through integrated phosphoproteomics and RNA-seq analyses.