Alberto Bardelli

This study shows adrenergic signaling promotes a pro-tumorigenic B cell state in colorectal cancer by altering their transcriptome and function, linking neuronal activity to immune responses and patient survival.

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

The paper shows that DC-based therapy enhances CD8 T cell responses to neoantigens in lung tumors, particularly in high TMB tumors.