Miguel Quintela-Fandiño

This paper introduces a breast-specific epigenetic clock (BTEC) that accurately predicts chronological age and reveals age-related DNA methylation changes in breast tumors and adjacent tissues.

PATH-IC uses generative AI to predict breast cancer genomic subtypes from histology images, achieving high accuracy and correlating with clinical outcomes.

QUICHE identifies low-prevalence cellular niches in spatial datasets, outperforming existing methods, and reveals structural anti-tumor immune responses in TNBC.

The paper evaluates how new DNA methylation arrays affect existing epigenetic age models and develops a cross-compatible model for 450k, EPICv1, and EPICv2 arrays.