Author

Elizabeth MacLean

University of OxfordORCID 0000-0003-1680-4292Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:virus· 1

Frequent Co-Authors

Andre Schutzer GodoyiD· 2 shared Anu V. ChandraniD· 2 shared Blake H. BalcombiD· 2 shared Charles W.E. TomlinsoniD· 2 shared Charline GiroudiD· 2 shared Conor Francis WildiD· 2 shared D. FearoniD· 2 shared Eleanor WilliamsiD· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Andre Schutzer GodoyORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 29, 2024

Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions

Ryan M. Lithgo, Charles W.E. Tomlinson, M. Fairhead…·F. von Delft

This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.

2 citations

virusexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivPreprintApr 29, 2024

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

Ryan M. Lithgo, Charles W.E. Tomlinson, M. Fairhead…·F. von Delft

The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.

5 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky