Author
Eleanor Williams
University of OxfordORCID 0000-0002-1331-9518Unclaimed ORCID profile · follow to get notified of new preprints
Additional preprints under this name without ORCID
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2021-2026 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author links6 papers
Recent·Most cited
- BiochemistryNature CommunicationsPeer-reviewed
Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors
Xiaomin Ni, R. Blake Richardson, Andre Schutzer Godoy…·F. von Delft
The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.
18 citationstop 3% - BiochemistrybioRxivPreprint
Crystallographic fragment screen of Enterovirus D68 3C protease and iterative design of lead-like compounds using structure-guided expansions
Ryan M. Lithgo, Charles W.E. Tomlinson, M. Fairhead…·F. von Delft
This study identifies fragments binding to EV-D68 3C protease through crystallography and expands them into lead-like compounds, revealing novel binding modes and structural insights for drug design.
2 citations - BiochemistrybioRxivPreprint
Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals
Ryan M. Lithgo, Charles W.E. Tomlinson, M. Fairhead…·F. von Delft
The paper identifies 75 fragments that bind to Coxsackievirus A16 2A protease, including 38 unique compounds in the active site, offering a path for broad-spectrum anti-enteroviral inhibitors.
- Molecular BiologybioRxivPreprint
A selection of Golden Gate vectors to simplify recombinant protein production in Escherichia coli
M. Fairhead, L. Koekemoer, Eleanor Williams, F. von Delft
The paper describes a set of Golden Gate vectors for efficient recombinant protein production in E. coli, with high cloning efficiency and useful tags and secretion signals.
4 citations - Molecular BiologyJCI InsightPeer-reviewed
Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva
Eleanor Williams, Jana Bagarova, Georgina Kerr…·Alex N. Bullock
The paper identifies saracatinib as a potent ALK2 inhibitor effective in preventing heterotopic ossification in FOP models.
73 citationstop 1%