Zhengting Zou

This study compares human and rodent PD1 proteins, finding rodent PD1 has weaker inhibitory activity and stronger tumor immunity due to evolutionary changes in Shp2 recruitment.

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

This study identifies a mutation in SLC2A11B as the genetic basis for pearl iris color in domestic pigeons, linking it to domestication and evolutionary changes in avian pigmentation.