Author

Lin Chen

Chinese Academy of Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Aniruddh Patel· 1 shared B Y ZhangiD· 1 shared Bing YuiD· 1 shared Can Peng· 1 shared Chen Yuke· 1 shared Cheng LuoiD· 1 shared Cheng Qian· 1 shared Christine Caron· 1 shared

Activity by Year

2016-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperNeuroscience

Aniruddh Patel

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4 papers

Recent·Most cited

Validation of MHPC512: A Publicly Available Special-Purpose Supercomputer for Molecular Dynamics Simulations of Biomolecular Systems

Lin Chen, Yuhan Chen, Ziqi Cheng, Jing Guo, Ming He, Huan Li, Xinyu Li, Zhen Li, Jule Ma, Shuo Ma, Can Peng, Cheng Qian, Zhi Qu, Sun Xian-gang, Xuan Tang, , Ye Mei

The paper validates MHPC512, a special-purpose supercomputer for molecular dynamics simulations, showing it produces results consistent with established software.

bioRxiv · Jun 11, 2026 · PreprintMolecular Biology

Causal associations between plasma proteins and prostate cancer: a Proteome-Wide Mendelian Randomization

Lin Chen, Gu Yanlun, Chen Yuke, Yu Wei, Zhou Ying, Rong Zhuona, Xiaocong Pang

This study identifies causal associations between plasma proteins and prostate cancer risk using Mendelian randomization, finding 193 associated proteins and potential drug targets.

eLife · Nov 17, 2025Peer-reviewedGenetic & Genomic Medicine

Evolutionary fingerprint in rodent PD1 confers weakened activity and enhanced tumor immunity compared to human PD1

Takeya Masubuchi, Lin Chen, Nimi Marcel, George A. Wen, Christine Caron, Jibin Zhang, Yunlong Zhao, Gerald P. Morris, Xu Chen, Stephen Μ. Hedrick, Li‐Fan Lu, Chuan Wu, Zhengting Zou, Jack D. Bui, Enfu Hui

This study compares human and rodent PD1 proteins, finding rodent PD1 has weaker inhibitory activity and stronger tumor immunity due to evolutionary changes in Shp2 recruitment.

Science Immunology · Jan 3, 2025Peer-reviewedImmunology

Temporal Modulations Reveal Distinct Rhythmic Properties of Speech and Music

Nai Ding, Aniruddh Patel, Lin Chen, Henry Butler, Cheng Luo, David Poeppel

This study compares the slow temporal modulations in speech and music across languages and instruments, finding distinct rhythmic patterns that can reliably distinguish the two.

bioRxiv · Jun 18, 2016Neuroscience