Enfu Hui

This study shows that PD1-induced Shp2 phase separation forms dynamic condensates that organize inhibitory signaling by selectively partitioning substrates, thereby suppressing T cell activation.

This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.

This study compares human and rodent PD1 proteins, finding rodent PD1 has weaker inhibitory activity and stronger tumor immunity due to evolutionary changes in Shp2 recruitment.