Author

Yael Fridmann Sirkis

Weizmann Institute of ScienceORCID 0000-0003-1733-2952Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Adva MechalyiD· 1 shared Andrew B Dippel· 1 shared Ariel TennenhouseiD· 1 shared Christopher Domalewski· 1 shared Daniel ChristiD· 1 shared Dorry X Zhao· 1 shared Gilad KaplaniD· 1 shared Isabel G ElliottiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Adva MechalyORCID

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1 paper

Recent·Most cited

Synthetic BiologybioRxivPreprintNov 26, 2025

Energy-guided combinatorial co-optimization of antibody affinity and stability

Ariel Tennenhouse, Adva Mechaly, Tony Pham…·Sarel Jacob Fleishman

This paper introduces LAffAb, a method to co-optimize antibody affinity and stability through combinatorial mutation design, achieving significant affinity gains while maintaining developability.

2 citations

protein structureexperimental assay

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