Christy M. Hoffmann

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.

The paper uses CellOracle to analyze GRN reconfiguration during fibroblast to iEP reprogramming, identifying Fos and Yap1 as key factors for successful conversion.

Gene regulatory networks inferred from single-cell transcriptome and epigenome data are perturbed in silico to predict transcription-factor perturbation outcomes and to nominate factors that raise reprogramming yield.

The paper profiles transcriptional diversity across skeletal, smooth, and cardiac muscles in mice and rats, revealing extensive gene expression differences and disease associations.