Author

Ellen G. Harding

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Philip A. RuzyckiiD· 3 shared Brian S. ClarkiD· 2 shared Sohini Rebba· 2 shared Alaina UrmaniD· 1 shared Aleksandra M. KrzywańskaiD· 1 shared Andi K. CaniiD· 1 shared Chi‐Kuo HuiD· 1 shared Christy M. HoffmanniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersNeuroscience

Philip A. RuzyckiORCID

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3 papers

Recent·Most cited

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina

Ning Shen, Michael J. Fitzpatrick, Ellen G. Harding, Sohini Rebba, Florentina Soto, Philip A. Ruzycki, Daniel Kerschensteiner

The paper identifies neuroprotective genes in RP using CRISPR screens in mice and human retinal models, showing that UFD1 and UXT overexpression preserves photoreceptors and function.

Neuron · Apr 9, 2026Peer-reviewedNeuroscience

Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development

Ismael Hernández‐Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy M. Hoffmann, Sohini Rebba, Ellen G. Harding, Qiang Li, Fengbiao Mao, Andi K. Cani, Shiming Chen, Meelad M. Dawlaty, Rajesh C. Rao, Philip A. Ruzycki, John R. Edwards, Brian S. Clark

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.

PLoS Biology · Aug 4, 2025Peer-reviewedDevelopmental Biology

Age-related dysregulation of the retinal transcriptome in African turquoise killifish

Steven Bergmans, Nicole C. L. Noel, Luca Masin, Ellen G. Harding, Aleksandra M. Krzywańska, Julie D. De Schutter, Rajagopal Ayana, Chi‐Kuo Hu, Lut Arckens, Philip A. Ruzycki, Ryan B. MacDonald, Brian S. Clark, Lieve Moons

This study uses bulk and single-cell RNA-seq to analyze age-related transcriptome changes in the African turquoise killifish retina, identifying oxidative stress, gliosis, and inflammageing, and highlighting dysregulation of retinal disease genes.

Aging Cell · May 14, 2024Peer-reviewedNeuroscience