Author
Wellcome Centre for Cell BiologyORCID 0000-0003-1860-5772Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Natalia Y. Kochanova, Moonmoon Deb, Marco Borsò…·William C. Earnshaw
The paper uses mass spectrometry to analyze histone modifications during mitotic entry, identifying three phosphorylation programs and showing H3 T3 phosphorylation marks heterochromatin, not just centromeres.
Kumiko Samejima, Johan Harmen Gibcus, Sameer Abraham…·William C. Earnshaw
In DT40 cells, condensins displace extrusive cohesin, bypass cohesive cohesin and stall against each other while extruding ~1-3 kb/sec, yielding irregular helical chromatids of consecutive loops.
Avinash V. Dharmadhikari, Maria Alba Abad, Reza Maroofian…·Universitat Autònoma de Barcelona. Departament de Medicina
The paper identifies SPOUT1/CENP-32 as a causative gene for SpADMiSS, linking its dysfunction to mitotic spindle defects and neurodevelopmental disorders.
Johan Harmen Gibcus, Kumiko Samejima, Anton A. Goloborodko…·Job Dekker
The paper shows mitotic chromosomes form through condensin-mediated disassembly of interphase chromatin and helical winding of loop arrays during prophase and prometaphase.