Masanori Iseki

This study creates a human myeloid cell model of VEXAS syndrome with UBA1 mutations, showing increased TNF-induced cell death and DAMP release.

This study identifies an Nkx2.3-Nr5a1 gene regulatory axis critical for spleen-specific vascular architecture and marginal zone formation in mice.

This study shows that EBI3 contributes to TLR7-induced splenomegaly and bicytopenia through IL-27, as demonstrated by IMQ treatment in mice.