BioinformaticsbioRxivPreprint
Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores
Eva Smorodina, Montader Ali, Klara Kropivšek…·Victor Greiff
The paper evaluates AI-based antibody-antigen structure prediction methods, finding that confidence scores often fail to distinguish correct from incorrect pairings, even with increased sampling.