Karren Yang

The paper uses Perturb-seq to systematically study 1,130 E3 ligases and their roles in inflammatory responses in dendritic cells, revealing co-functional modules and genetic interactions.

This paper introduces an autoencoder-based method to integrate single-cell imaging and sequencing data, identifying sub-populations of human naive CD4+ T-cells.

This paper introduces ImageAEOT, a method combining autoencoders and optimal transport to infer single-cell trajectories from imaging data, validated on chromatin images of cancer cells and tissues.