Douglas W. DeSimone

This study identifies ARHGAP10 as a novel gene associated with congenital heart disease and ciliopathy through integrative functional genomics in Xenopus tropicalis.

The paper develops a Cellular-Potts model to study how cohesotaxis, tissue geometry, and cell intercalation influence collective migration velocity in Xenopus mesendoderm.

The paper characterizes convergent thickening in Xenopus gastrulation, showing it generates tensile forces through changes in tissue affinity.

The paper shows that integrin adhesion and PDGFr signaling work together to drive directional migration of Xenopus mesendoderm cells without PDGF-A ligand.

This study shows plakoglobin is essential for morphogenetic events by regulating cell-cell and cell-matrix adhesion during Xenopus gastrulation.