Simge Senyuz

The paper identifies a 127-gene core network in human astrocytes linking aging to neurodegenerative and cardiovascular diseases through proteostasis and stress signaling.

This study identifies key protein interactions and pathways involved in vascular cognitive impairment by analyzing protein-protein interaction networks and conformational changes.

The paper introduces DiPPI, a curated dataset of drug-like molecules in protein-protein interfaces, along with a website for drug repurposing studies, containing 55,135 interface-drug interactions.

The paper identifies novel protein interactions involving mutant APP, TP53, and MAPKs in vascular cognitive impairment using network analysis and molecular modeling.

The paper identifies shared proteins and pathways between cardiovascular and cognitive diseases using protein interaction network analysis, highlighting oxidative and glycative stress mechanisms in vascular cognitive impairment.

The paper identifies FDA-approved drugs that may bind to structurally similar protein-protein interfaces in the Ras/Raf/MEK/ERK pathway, increasing structural coverage from 21% to 92% using PRISM.