BioinformaticsbioRxivPreprint
Conformational diversity and protein-protein interfaces in drug repurposing in Ras signaling pathway
Ahenk Zeynep Sayin, Zeynep Abali, Simge Senyuz…·Özlem Keskin
The paper identifies FDA-approved drugs that may bind to structurally similar protein-protein interfaces in the Ras/Raf/MEK/ERK pathway, increasing structural coverage from 21% to 92% using PRISM.
DOI 10.1101/2023.08.03.551801