Amy E. Moran

This study identifies distinct transcriptional features in fibroblasts and myeloid cells of ICI-LP compared to LP, highlighting differences in IGF1, JAK-STAT, and interferon pathways.

This study constructs the Prostate Cancer Cell Atlas by analyzing ~710,000 single cells from 197 human samples to characterize cell states and dynamics across prostate cancer progression stages.

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

The paper develops a framework to analyze scRNA-seq data and identify gene-regulatory networks linked to CD8 T cell exhaustion in tumor and viral infection contexts.

Scissor identifies cell subpopulations from single-cell data correlated with specific phenotypes using clinical information, revealing biologically relevant subpopulations in lung and melanoma cancers.