Canping Chen

This study shows that GNL3 SUMOylation is essential for homologous recombination repair of DNA double-strand breaks and identifies potential therapeutic targets in breast cancer.

This study shows that HuR promotes immune evasion in PDAC by inhibiting T cell infiltration and function, suggesting HuR as a therapeutic target with immunotherapy.

This study shows that MHC-II expression in pancreatic cancer cells correlates with immune infiltration and improves immunotherapy response in mouse models.

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

This study shows that HuR in pancreatic cancer cells enhances angiogenesis by modulating extracellular vesicle signaling to endothelial cells, increasing their migratory and tube-forming abilities while reducing ICAM-1 expression.

The paper identifies loss of stromal KITL as a mechanism promoting tumor progression in the pancreas by disrupting tissue homeostasis.

This study constructs the Prostate Cancer Cell Atlas by analyzing ~710,000 single cells from 197 human samples to characterize cell states and dynamics across prostate cancer progression stages.

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

PENCIL identifies phenotype-relevant cell subpopulations from single-cell data using a supervised learning framework with feature selection and trajectory prediction capabilities.