Zheng Xia

This study quantifies cancer stemness in prostate cancer across progression stages, showing its association with therapy resistance, poor survival, and lineage plasticity.

This study shows that GNL3 SUMOylation is essential for homologous recombination repair of DNA double-strand breaks and identifies potential therapeutic targets in breast cancer.

ACCREDIT improves cross-modal image registration by detecting failures and automatically recovering alignments, outperforming existing methods in accuracy and robustness.

This paper introduces a computational framework for true 3D spatial reconstruction of tissues, demonstrating improved fidelity over 2D methods across multiple spatial omics modalities.

The paper identifies global 3'UTR lengthening in SCNC through APA and develops a neural network model to classify SCNC using APA signatures.

This study shows that HuR promotes immune evasion in PDAC by inhibiting T cell infiltration and function, suggesting HuR as a therapeutic target with immunotherapy.

This study shows that MHC-II expression in pancreatic cancer cells correlates with immune infiltration and improves immunotherapy response in mouse models.

This study examines liver transcriptional changes during lactation and weaning in mice, finding similarities between liver involution and pre-metastatic niches, with implications for breast cancer metastasis.

This study shows PIN1 promotes cellular plasticity and immune changes in chronic pancreatitis, with genetic or pharmacological inhibition reducing disease severity.

This study shows that HuR in pancreatic cancer cells enhances angiogenesis by modulating extracellular vesicle signaling to endothelial cells, increasing their migratory and tube-forming abilities while reducing ICAM-1 expression.

The paper identifies loss of stromal KITL as a mechanism promoting tumor progression in the pancreas by disrupting tissue homeostasis.

This study constructs the Prostate Cancer Cell Atlas by analyzing ~710,000 single cells from 197 human samples to characterize cell states and dynamics across prostate cancer progression stages.

This study shows that vitamin D's anti-cancer effects are reduced in post-wean mice due to altered liver metabolism, highlighting the importance of reproductive history in treatment efficacy.

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

PathExpSurv integrates known biological pathways with neural networks to improve survival analysis in cancer, identifying disease-related genes through pathway expansion.

This study identifies a muscle-specific MEF2D2 isoform that enhances ketone body utilization and running capacity in mice by regulating ketolytic gene expression.

PENCIL identifies phenotype-relevant cell subpopulations from single-cell data using a supervised learning framework with feature selection and trajectory prediction capabilities.

Scissor identifies cell subpopulations from single-cell data correlated with specific phenotypes using clinical information, revealing biologically relevant subpopulations in lung and melanoma cancers.

The paper introduces sci-MET, a scalable single-cell DNA methylation sequencing method, achieving 69% read alignment rates and successfully deconvolving a mixture of three human cell lines.

Poly(A)-ClickSeq enables high-quality RNA-seq libraries of poly(A) site junctions without RNA enrichment or fragmentation, revealing new poly(A) sites and APA regulation.

The paper identifies alternative splicing transitions during postnatal skeletal muscle development and shows their role in calcium handling through calcineurin A isoform regulation.