Pharmacology & ToxicologyNeuropsychopharmacologyPeer-reviewed
RAPID HIPPOCAMPAL SYNAPTIC POTENTIATION INDUCED BY KETAMINE METABOLITE (2R,6R)-HYDROXYNORKETAMINE PERSISTENTLY PRIMES SYNAPTIC PLASTICITY
Kyle A. Brown, Musa Iyiola Ajibola, Todd D. Gould
This study shows that HNK rapidly potentiates hippocampal synapses and primes long-term plasticity through PKA-dependent mechanisms, suggesting new antidepressant strategies.
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