Todd D. Gould

The paper shows that estradiol, not testosterone, mediates stress susceptibility in male mice by modulating specific neural circuits, and brain delivery of estradiol prevents depression-like behaviors.

This study shows that HNK rapidly potentiates hippocampal synapses and primes long-term plasticity through PKA-dependent mechanisms, suggesting new antidepressant strategies.

The paper investigates how ketamine's metabolism via hepatic CYP450 enzymes affects its antidepressant effects, finding that (6)-HNKs mediate sustained antidepressant actions.

This study shows that the sex of human experimenters affects mouse behaviors, stress responses, and drug responses like ketamine, mediated by CRF neurons.