Rasa J Vilimas

This study compares genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumors in SCLC patients, finding cfDNA reflects tumor mutations, identifies resistance mechanisms, and tracks tumor evolution.

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.