Anish Thomas

Sensitizing tumor response to topoisomerase I antibody drug conjugate by selective CDK7 inhibition

This study shows that Q901, a CDK7 inhibitor, enhances cancer susceptibility to TOP1 inhibitors by stabilizing TOP1-DPCs and suppressing DNA repair pathways.

SCLC TumorMiner: A Genomics Platform for Small Cell Lung Cancer Precision Oncology

SCLC TumorMiner is a genomics platform that provides molecular classification, biomarker identification, and drug-response analysis for small cell lung cancer using integrated datasets from multiple institutions.

Spindle Assembly Checkpoint Competency Determines Sensitivity to KIF18A Inhibition in Small-Cell Lung Cancer

This study identifies SAC competency as the determinant of sensitivity to KIF18A inhibition in SCLC, offering a predictive biomarker for targeted therapies.

Spatially Organized Tertiary Lymphoid Structures Emerge in Small Cell Lung Cancer and Associate with Improved Survival

The paper identifies spatially organized tertiary lymphoid structures in small cell lung cancer and links their presence to improved patient survival.

Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastases

Proteomic Profiling Identifies CLDN3 as a Tumor-Selective Therapeutic Target in Small Cell Lung Cancer

The paper identifies CLDN3 as a tumor-selective target in SCLC using proteogenomic analysis and validates its therapeutic potential with a monoclonal antibody.

Hepatobiliary Progenitor-like Reprogramming in Liver Metastases

This study identifies hepatobiliary progenitor-like reprogramming in liver metastases, driven by TGF-β and hypoxia, and shows its association with poor survival.

HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc- Driven Small Cell Lung Cancer

This study shows that HDAC inhibition with entinostat enhances immunotherapy response in SCLC by reprogramming tumor immunology and neuroendocrine status.

Bidirectional coupling among EMT, AXL-RB1 signaling and lineage switch drives resistance to osimertinib and worse clinical outcomes in NSCLC

Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer

The paper identifies basal cells as the origin of neuroendocrine-tuft-like tumors in SCLC, revealing lineage plasticity and transcriptional states that mirror human cancer and normal cell injury responses.

Metastatic organotropism in small cell lung cancer

This study identifies key cellular programs and pathways driving metastatic organotropism in small cell lung cancer using preclinical models and multiomic profiling.

SMARCA4 is essential for early-stage tumor development but its loss promotes late-stage cancer progression in small-cell lung cancer

This study shows SMARCA4 is important for early tumor development in SCLC but its loss promotes late-stage cancer progression through altered tumor-NK cell interactions.

Lamin A/C Deficiency Drives Genomic Instability and Poor Survival in Small-Cell Lung Cancer through Increased R-loop Accumulation

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

Genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumor

This study compares genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumors in SCLC patients, finding cfDNA reflects tumor mutations, identifies resistance mechanisms, and tracks tumor evolution.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

Integrative analysis of pharmacogenomics in major cancer cell line databases using CellMinerCDB

CellMinerCDB integrates pharmacogenomic data from multiple cancer cell line databases to identify drug response determinants, reproducibility, and novel genomic signatures.