NeuroscienceJournal of Clinical InvestigationPeer-reviewed
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
Kaitlin Weskamp, Elizabeth M.H. Tank, Roberto Miguez…·Sami J. Barmada
This study shows that shortened TDP43 isoforms, upregulated by neuronal hyperactivity, drive TDP43 pathology in ALS by forming cytoplasmic inclusions and sequestering full-length TDP43.