Andrea Serio

Dynamic modelling of human neural crest development using a bioengineered stem cell organoid system

This paper introduces a bioengineered stem cell organoid system to model human neural crest development, showing it recapitulates key developmental dynamics and can be used for cross-species validation.

Brain-derived neurotrophic factor amplifies neuron-intrinsic programs to enhance axonal regeneration in human motor neurons

This study shows BDNF enhances axonal regeneration in human motor neurons by regulating RNA metabolism and cytoskeletal dynamics through kinase pathways.

Engineering Cortical Networks: An Open Platform for Controlled Human Circuit Formation and Synaptic Analysis In vitro

The paper introduces an open platform for creating functional cortical circuits using iPSC-derived neurons, enabling controlled network assembly and analysis of synaptic activity and connectivity.

VISIBLE: An imaging-driven system for sampling, biofabrication, and manipulation of complex biological models

VISIBLE is a system for real-time manipulation and bioprinting of complex in vitro models, enabling precise interventions and improving reproducibility in biomedical research.

Multimodal profiling unveils a reversible breast basal-like cell state in AKT-inhibitor resistant tumours

This study identifies a reversible basal-like cell state in AKT-inhibitor resistant triple negative breast cancer using multimodal profiling and lineage tracing.

Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity

The paper generates morphologically distinct astrocyte subtypes from human iPSCs and links their shape, function, and reactivity.

The V-ATPase/ATG16L1 axis is controlled by the V1H subunit

This paper identifies the V1H subunit of V-ATPase as a regulator of ATG16L1 recruitment in response to pH gradient disruption, linking V-ATPase function to autophagy activation.

Axonal length determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform

This study shows that axon length in human motor neurons affects their homeostatic mechanisms, revealing length-dependent molecular adaptations in cytoskeleton, translation, and mitochondria.

Automated and unbiased classification of motor neuron phenotypes with single cell resolution in ALS tissue.

The paper develops an automated image processing pipeline with machine learning to classify motor neuron phenotypes in ALS tissue at single-cell resolution, revealing common morphological aberrations and validating their discriminative power between ALS and healthy tissue.

Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS

This study shows that shortened TDP43 isoforms, upregulated by neuronal hyperactivity, drive TDP43 pathology in ALS by forming cytoplasmic inclusions and sequestering full-length TDP43.