Markus Hackl

This study investigates how mechanical pulling affects the unbinding of a cellulosomal carbohydrate-binding module from cellulose using simulations and experiments, showing that pulling orientation significantly impacts unfolding and unbinding dynamics.

The paper develops a pull-down binding assay to assess the directional binding preferences of cellulose-binding modules to cello-oligosaccharides, revealing similar affinity for cellohexaose but not cellopentaose.