Lan Jiang

This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.

CellMemory interprets out-of-distribution cells using a bottlenecked Transformer, outperforming pre-trained models and enabling accurate analysis of spatially resolved single-cell data.

The paper identifies fetal cis-regulatory elements in the human genome using single-cell multi-omics analysis, revealing thousands of organ- and cell-type-specific regulatory elements.