Cassandra White

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

This study identifies 12 enhancers in the 9p21.3 CAD risk locus that regulate MTAP, modulating vascular cell-state transitions and CAD risk through stress-responsive mechanisms.

This paper develops a platform to model and manipulate human microglial states in vitro using single-cell RNA sequencing and genetic tools, identifying disease-associated transcriptional signatures.

The paper shows VIP interneurons in mouse visual cortex have complementary contrast tuning to SST neurons and synergistically respond to visual motion and locomotion, enhancing behaviorally-relevant stimuli while maintaining network stability.