RAD51 promotes non-homologous genetic rearrangements that are prevented by 53BP1
Josée Guirouilh‐Barbat, Wei Yu, Loélia Babin, Elisa Yaniz‐Galende, Tatiana Valentinovna Popova, Ayeong So, Chloé Lescale, Marc‐Henri Stern, Erika Brunet, Ludovic Deriano, Bernard S. López
The paper shows RAD51 and BRCA2 promote non-homologous genetic rearrangements, which are prevented by 53BP1, and links BRCA2 proficiency to increased non-homologous sequence capture in breast tumors.
bioRxiv · Sep 14, 2019 · PreprintMolecular Biology