Bernard S. López

This study shows NLRP3 promotes homologous recombination by interacting with REV7, enhancing DNA repair and affecting PARP inhibitor sensitivity.

This study shows that cancer cell lines exhibit dysregulated LoL-DDR, leading to increased RIR and 8-oxoG accumulation, creating a replication stress-ROS vicious circle that promotes tumorigenesis.

This study shows PKA promotes NHEJ over resection in DSB repair by interacting with 53BP1, highlighting PKA's role in DNA damage response and genome stability.

This study identifies a BRCA2 variant causing primary ovarian insufficiency without cancer or Fanconi anemia, showing residual HR function in patient cells.

This study shows RAD51 inhibits non-conservative DNA repair pathways by blocking ssDNA annealing, independent of its catalytic activity.

The paper shows RAD51 and BRCA2 promote non-homologous genetic rearrangements, which are prevented by 53BP1, and links BRCA2 proficiency to increased non-homologous sequence capture in breast tumors.