Chenghui Zhao

The paper uses single-molecule long-read sequencing to identify structural variants driving high-altitude adaptation in Tibetans, revealing their role in gene regulation and biological functions.

DeepHiC enhances Hi-C data resolution using a generative adversarial network, improving chromatin loop and TAD detection accuracy from low-coverage sequencing data.

The paper models the time-resolved succession of epigenetic regulation during early mammalian development and identifies key epigenetic events that coordinate transcriptional programs at different stages.

This study integrates multiple analyses to characterize human essential genes and develops a web platform for their comprehensive interpretation.